Not Yet RecruitingNot Applicable

Pilot MRI Study on Osteopathic Manipulation for Myofascial Pain Syndrome

20 participantsStarted 2024-08-31

Plain-language summary

The goal of this clinical trial is to conduct MRI studies on adults with myofascial pain syndrome (MPS) to identify important MRI biomarkers that respond to OMT (osteopathic manipulation therapy) and investigate the feasibility of implementing MRI study and OMT in this population. The main outcomes of the study include: * Determine whether biomarkers measured by MRI can differentiate normal tissues and MTrP (myofascial trigger point). * Test the responsiveness of the biomarkers identified by MRI to the proposed intervention, OMT, in patients with MPS of the upper back. Researchers will compare participants who will receive one session of OMT (Group 1 - Experimental Condition) and participants who will not receive any treatment (Group 2 - Control Condition) to see how the MRI-identified biomarkers respond to the intervention. Participants will complete the following: * Clinical screening * MRI measures * Battery of self-report surveys * Clinical/Physical Function Assessment

Who can participate

Age range18 Years – 64 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * MPS of the upper back with MTrPs as specified by Travell and Simons, with the confirmation of ultrasound procedure. * Normal neurological examination including manual muscle testing, sensory exam, and deep tendon reflexes. * English-speaking. * Age 18 - 64 and reside in the community. Exclusion Criteria: * Malignancy. * Major psychiatric disorders, such as bipolar disorder and depression. * Cognitive impairment * Skin lesion(s) on the shoulders and upper back. * Systematic pain condition, such as Fibromyalgia. * Previous surgical procedures in the spine, shoulder, and/or back within six months. * Pregnancy. * BMI of 40 or higher. * Any health conditions that prevent participants from performing the experimental procedure * Any contraindications of MRI procedure such as implantable cardiac devices (pacemakers, defibrillator, etc.), aneurysm clips, or metallic shoulder and/or spinal cord implants or screws.

What they're measuring

MRI Biomarkers - Structural MRI

Timeframe: For experimental group (Group 1): Outcomes will be assessed at Time 1 and Time 2 within the 4 hour duration; For no intervention group (Group 2): Outcomes will be assessed at Time 1 within the 4 hour duration.

MRI Biomarkers - Diffusion Tensor MRI (DTI)

fMRI

Trial details

NCT IDNCT06538727

SponsorAuburn University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-04-30

Contact for this trial

Pao-Feng Tsai, PhD

334-844-6807 pzt0022@auburn.edu

View on ClinicalTrials.gov More Myofascial Pain Syndrome trials