Effects of tDCS Combined With Retrieval Practice on Semantic Memory in Patients With Schizophrenia (NCT06538259) | Clinical Trial Compass
CompletedNot Applicable
Effects of tDCS Combined With Retrieval Practice on Semantic Memory in Patients With Schizophrenia
China52 participantsStarted 2023-07-24
Plain-language summary
The semantic processing deficit stands as a central feature of cognitive abnormalities in schizophrenia. Both transcranial direct current stimulation (tDCS) and retrieval practice have been demonstrated as external techniques capable of ameliorating the semantic processing deficit in individuals with schizophrenia. The inquiry examines whether the combined effect of tDCS and retrieval practice, following tDCS intervention targeting the left dorsolateral prefrontal cortex (L-DLPFC) in patients with schizophrenia, contributes to the preservation of semantic memory in these individuals.
Investigators recruited 52 patients diagnosed with schizophrenia from hospitals. After five consecutive days of tDCS intervention (2 mA × 20 mins, twice per day), Investigators administered a word list memorization task comparing retrieval practice and restudy strategies. Subsequently, Investigators observed their immediate and delayed memory performance through tests.
Who can participate
Age range19 Years – 60 Years
SexALL
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Inclusion criteria
✓. Meeting the diagnostic criteria for schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5);
✓. Aged 18 years or older, regardless of gender, with an educational level of elementary school or above;
✓. All patients received stable-level antipsychotic medication treatment, were in a stable phase of disease treatment, able to understand the testing requirements, and cooperated to complete all research tasks;
✓. No history of neurological disorders or other serious physical illnesses, and no history of intellectual disability;
✓. No color blindness, color weakness, or other color vision impairments, with normal vision or corrected vision.
Exclusion criteria
✕. Clear cognitive impairment caused by somatic or cerebral organic lesions, such as cerebrovascular diseases, traumatic brain injury, etc;
✕. Individuals with mental disorders caused by substance dependence or abuse, or the use of psychoactive substances;