Effects of Anthriscus Sylvestris Leaves on Mild Knee Osteoarthritis (NCT06535204) | Clinical Trial Compass
CompletedNot Applicable
Effects of Anthriscus Sylvestris Leaves on Mild Knee Osteoarthritis
South Korea100 participantsStarted 2019-06-24
Plain-language summary
Osteoarthritis (OA) is a common degenerative joint disorder that causes pain, stiffness, and functional impairment. Current treatments for OA are limited to symptom relief and have potential side effects. Anthriscus sylvestris leaves are a natural remedy that has been shown to have anti-inflammatory and cartilage-protective effects in animal models of OA.
Who can participate
Age range40 Years – 75 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 40 to 75 years, regardless of gender
* Individuals with a Visual Analogue Scale (VAS) score of 3/10 or higher
* Individuals with a Kellgren \& Lawrence grading scale of grade 1 or 2, determined by 'Both Knee Joint AP/LAT' radiographs
* Individuals who have had a washout period of at least 4 weeks for arthritis- related medications or health supplements
* Individuals capable of normal physical activity who have voluntarily provided written informed consent to participate in this study
Exclusion Criteria:
* Individuals with a history of fractures within the past year
* Individuals with osteophytes around the joints, irregular joint surfaces, or subchondral bone cysts, indicating moderate arthritis
* Individuals currently undergoing treatment for a diagnosed thyroid disorder
* Individuals with kidney disease or serum creatinine levels of 1.4 mg/dL or higher
* Individuals with proteinuria of 2+ or higher
* Individuals with liver disease or AST or ALT levels of 100 IU/L or higher
* Individuals with uncontrolled hypertension or heart conditions such as angina or myocardial infarction
* Individuals taking medication for psychiatric disorders, except for intermittent medication for sleep disorders
* Individuals who have taken herbal or medicinal decoctions within the past two months
* Individuals who have received other investigational drugs within the past four weeks
* Individuals who need to continuously take medication that may affect the outco…
What they're measuring
1
WOMAC(Western Ontario and Mcmasters Universities)
Timeframe: Visit 2 (baseline) and Visit 3 (during the trial, 4week±7day) and Visit 4 (end of the trial) (12week±7day)