Evaluation of Gut Microbiota and Its Associated Resistome in FMT Donors and Recipients Due to Recurrent Clostridiodes Difficile Infection

Inclusion criteria * patients with rCDI (\> 18 years) to whom faecal microbiota transplantation is indicated, without other pathologies or prolonged hospitalization periods * donors: healthy volunteers aged between 18 and 50 years * Patients capable of expressing consent Exclusion criteria * antibiotic therapies in the last 30 days * treatments with prebiotics - probiotics - postbiotics in the last 60 days * colonization by MDR or XDR pathogens * presence of pre-existing or ongoing intestinal pathologies (Inflammatory Intestinal Diseases, chronic hepatitis, celiac disease, neoplasms, previous large intestinal resections) * ongoing diarrhea of any origin (defined as more than 6 watery stools per day and/or faecal volume greater than 250 ml in 24 hours) * severe septic state in progress * for donors: drug addiction, promiscuous sexual behaviour, use of drugs that can be excreted in the faeces with potential risk for recipients