Active — Not RecruitingNot Applicable

Real-World Data Study of Troriluzole-Treated Patients With Spinocerebellar Ataxia (SCA) Compared to a Matched Natural History Control

United States909 participantsStarted 2019-03-18

Plain-language summary

The purpose of this study is to leverage two sources of real-world data (RWD) to assess the effectiveness of troriluzole after three years of treatment in patients with SCA by comparison to an external control of untreated patients who were followed in a natural history cohort. Real world evidence of effectiveness will be assessed from the RWD sources to examine the treatment effects of toriluzole in SCA out to 3 years. Progression rates of SCA differ by genotype and long-term follow-up is needed to assess for potential efficacy in this rare disease.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Key Inclusion Criteria for troriluzole-treated participants (BHV4157-206): * Between the ages of 18-75 * Genetic confirmation of the following specific hereditary ataxias: SCA1, SCA2, SCA3, SCA6, SCA7, SCA8, and SCA10 * Screening f-SARA total score of ≥3 and score of ≥1 on gait item of the f-SARA. * Ability to ambulate 8 meters without human assistance (canes and other devices were allowed) * Subjects initially randomized to troriluzole Key Inclusion Criteria for participants selected from the natural history studies: * Between ages of 18-75 * CRC-SCA: either a genetic confirmation or a diagnosis of SCA 1, 2, 3, 6, 7, 8, and 10 in themselves or a family member; EUROSCA: genetic confirmation of SCA genotypes 1, 2, 3 and 6. Key Exclusion Criteria for troriluzole-treated participants (BHV4157-206 study): * Screening f-SARA score of 4 on any item of the f-SARA * Any other medical condition that could predominantly explain or contribute significantly to the subjects' symptoms of ataxia or that could confound assessment of ataxia symptoms Key Exclusion Criteria for participants selected from the natural history studies: • Treatment with troriluzole

What they're measuring

Change from Baseline in the total score of the modified functional Scale for the Assessment and Rating of Ataxia (f-SARA) at Year 3 in troriluzole-treated subjects is compared to natural history subjects from CRC-SCA

Timeframe: Up to 3 years of treatment

Trial details

NCT IDNCT06529146

SponsorBiohaven Therapeutics Ltd.

Sponsor typeINDUSTRY

Study typeOBSERVATIONAL

Primary completion2024-09-06