Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial
China619 participantsStarted 2026-01-19
Plain-language summary
The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to the traditional tidal volume and respiratory rate target, can improve clinical outcomes in adult participants undergoing pressure support ventilation.
The investigators propose a physiological-oriented assisted ventilation management that, if found effective, could potentially change the clinical practice for mechanical ventilation.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. PSV initiated during the last 24 hours;
✓. Mechanical ventilation expected to be required for at least 24-48 h by responsible physicians;
✓. The partial pressure of oxygen in arterial blood (PaO2)/inspired oxygen fraction (FiO2) ≤ 300 mmHg (measuring at clinical FiO2 and positive end-expiratory pressure PEEP);
✓. No sedation or stable sedation with Richmond Agitation Sedation Scale (RASS) of -2 to +1 or Riker's Sedation-Agitation Scale (SAS) of 3 to 4.
Exclusion criteria
✕. Age younger than 18 years old;
✕. Initiation of PSV before ICU admission;
✕. Duration of mechanical ventilation longer than 7 days before enrollment;
✕. History of neuromuscular diseases;
✕. Clinical suspicion of increased intracranial pressure;
✕
What they're measuring
1
Ventilator-free days (VFDs) at day 28 after enrollment.