Local Ischemic Postconditioning in Acute Ischemic Stroke

Inclusion Criteria: * Age ≥ 18 years old * Presenting with symptoms and signs consistent with acute anterior circulation ischemic stroke * Pre-stroke modified Rankin Score 0-1 * Baseline National Institute of Health Stroke Scale (NIHSS) score≥6 * Endovascular treatment can be initiated (femoral puncture) within 24 hours from stroke onset (stroke onset time is defined as last known well time) * Occlusion of the intracranial internal carotid artery, or the middle cerebral artery (MCA) (M1 or M2) and is the culprit artery * Ischemic core volume is \< 70 ml, mismatch ratio is \>1.8 and mismatch volume is \>15 ml as determined by CT perfusion imaging * Embolism verified as the etiology of occluded artery and modified Thrombolysis in Cerebral Infarction Score (mTICI) 2b or 3 achieved after mechanical thrombectomy. * Time from CT perfusion to reperfusion \< 2 hours * Informed consent signed Exclusion Criteria: * Stenosis of the proximal middle cerebral artery, internal carotid artery, or common carotid artery (≥50%) of the culprit artery * Evidence of internal carotid artery lesion that precludes the access and application of balloon guide catheter * Multiple vascular embolism on different pathways (e.g., bilateral MCA occlusions, or an MCA and a basilar artery occlusion) * Pre ischemic stroke within past 3 months * The expected survival time is less than 6 months, could not be followed at 90 days (such as patient with malignant tumor) * Currently pregnant, mental disease, advanc…