Coenzyme Q10 for Gulf War Illness: A Replication Study (NCT06515184) | Clinical Trial Compass
RecruitingPhase 3
Coenzyme Q10 for Gulf War Illness: A Replication Study
United States192 participantsStarted 2024-09-13
Plain-language summary
The purpose of this study is to assess whether a high quality preparation of ubiquinone (coenzyme Q10) benefits symptoms, function, and quality of life in veterans with Gulf War illness.
Who can participate
Age range
50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Meets both CDC and Kansas deployment and symptom inclusion criteria.
* Does not have a disqualifying condition.
* Able to travel to a local Quest facility for study blood draws.
* Adequate internet access to allow ZoomPro visit participation and remote survey completion.
* Health prior to the Gulf War rated as "very good" or "excellent" (to exclude persons who may have had other health conditions with different mechanisms as the cause of their symptoms).
* Willing to defer initiation of discretionary treatments or supplements during the expected course of study participation.
Exclusion Criteria:
* Participating in another clinical trial.
* Still-evolving adverse effects following another medication or health condition, such as covid or fluoroquinolone use.
* On Coumadin/ warfarin.
* Unable to participate for the required duration of the study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is described as a 'replication study' of Coenzyme Q10 for Gulf War Illness — does that mean there's already earlier research suggesting it might help, and if so, what did that earlier study show about safety and effectiveness?
2Since this is a Phase 3 trial comparing CoQ10 to a placebo, and the main outcome is tracking symptoms on a 20-item survey, how would I know whether I'm actually improving, and would I have access to my results after the study ends?
3CoQ10 is already available as an over-the-counter supplement — given that, how does participating in this trial differ from simply trying CoQ10 on my own, and is there a reason to do one versus the other?
4My Gulf War Illness symptoms include specific issues that might make some trials harder to manage day-to-day — can you look at what this trial's visit schedule and requirements look like, and help me figure out if the demands are realistic for my situation?
5Are there any standard-of-care treatments for Gulf War Illness that I should consider trying first before enrolling in a trial like this one, or is the evidence base for those options limited enough that a trial might actually be worth discussing sooner?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Number of symptoms (out of 20 on the UCSD Symptom Score Survey) showing more favorable change (trend or effect) on active treatment vs. on placebo.