Study of the Effect of HFA-152a and HFA-134a Propellants on Mucociliary Clearance in Healthy Participants

Inclusion Criteria: Participants are eligible to be included in the study only if all following criteria apply: * Male or Female, age 30 to 55 years * Body Mass Index (BMI): 18.0 to 32.0 kg/m2, inclusive, at screening * Weight: ≥50 kg * Nonsmokers or ex-smokers for more than 6 months with a smoking history of \<10 pack years * Status: healthy participants * Spirometry data. * Forced Expiratory Volume in 1 second (FEV1) ≥80% of predicted values. * FEV1: Forced vital capacity (FVC) ratio \>70%. * Females must be of nonchildbearing potential, and agree not to donate eggs (ova, oocytes) for the purpose of reproduction during the study intervention period and at least 30 days after the last dose of study intervention. * Male participants are eligible to participate if they agree to: * Refrain from donating sperm * Either be abstinent from heterosexual intercourse as their preferred and usual lifestyle (abstinent on a long term and persistent basis) and agree to remain abstinent * Or must agree to use a male condom when having sexual intercourse with a woman of childbearing potential (WOCBP) who is not currently pregnant. The female partner should additionally use a highly effective contraceptive method with a failure rate of \<1% per year. * All prescribed medication must have been stopped at least 30 days prior to admission to the clinical research centre based on investigator judgment. An exception is made for Hormonal Replacement Therapy (HRT), and occasional para…