Revealing Protective Immunity to Influenza Using Systems Immunology

Inclusion Criteria: * Able to understand and give informed consent * Participants of child bearing potential must agree to use effective birth control for the duration of the study. A negative urine pregnancy test must be documented prior to vaccination. Exclusion Criteria: * History of allergy or serious adverse reaction, including Guillain-Barré syndrome, to a vaccine or vaccine products * History of a medical condition resulting in impaired immunity such as active solid tumors, leukemia, lymphoma, chemotherapy or radiation therapy, autoimmune conditions, or splenic dysfunction. Persons with previous skin cancers or cured non-lymphatic tumors are not excluded from the study. * History of asthma, cochlear implant, or active cerebrospinal fluid leak * Use of immune modifying drugs including: systemic steroids for more than 1 week (such as prednisone \> 20mg/day), chronic administration (more than 14 days total) of immunosuppressive or immunomodulatory drugs in the prior 3 months * History of HIV, Hepatitis B or Hepatitis C infection * Chronic clinically significant medical problems that could be considered active or unstable (i.e diagnosed within the past 3 months or requiring a change in medication within the past 3 months). This is including (but not limited to): * Insulin dependent diabetes * Severe heart disease (including arrhythmias) * Severe lung disease * Severe liver disease * Severe kidney disease * Severe hypertension: defined as life-threatening co…