Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus (NCT06498180) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus
China29 participantsStarted 2024-12-31
Plain-language summary
The purpose of this clinical trial is to understand whether the combination of periodontal initial treatment under local anesthesia and glucocorticoids can improve the effectiveness of treatment for erosive oral lichen planus. It will also understand the safety of this treatment regimen.
This study is a single-center, parallel-group, randomized self-controlled trial. The researchers will compare the treatment of periodontal initial therapy combined with glucocorticoid therapy under local anesthesia with traditional glucocorticoid therapy to see if the treatment of periodontal initial therapy combined with glucocorticoid therapy under local anesthesia promotes the healing of erosive oral lichen planus.
Participants will:
One side received periodontal initial treatment combined with glucocorticoid under local anesthesia, while the other side received traditional glucocorticoid therapy Clinical examination at 2, 4, 8, and 12 weeks after treatment Note down the size of their erosion lesion area and periodontal clinical parameters
Who can participate
Age range18 Years – 75 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Existence of erosive oral lichen planus that lasts for more than 2 months
* Erosive lesions are located in the buccal mucosa and gingival buccal sulcus of the bilateral mandibular posterior teeth area
* The erosive lesions are mild to moderate (single or multiple small area erosions; 3mm ≤ longest diameter ≤ 10mm; 9mm2 ≤ total area of erosions ≤ 100mm2), and the degree of erosion on both sides is similar (the difference in the size of erosion on both sides does not exceed ± 25%)
* The plaque index in the area of erosive lesions is ≥ 3; Dental calculus index ≥ 2; Gingival index ≥ 2;
* Accompanied by stage II-IV extensive periodontitis
Exclusion Criteria:
* Pregnant women, lactating women, or women planning to conceive during the trial period
* Patients with coagulation dysfunction or other uncontrolled systemic diseases who cannot undergo periodontal treatment
* Has undergone basic periodontal treatment within the past 6 months
* Individuals with a history of allergy to local anesthetic drugs such as articaine
* Individuals with contraindications to glucocorticoids
* Patients with lesion area erosion caused by trauma or chemical stimulation
* Patients with mental disorders who are difficult to cooperate with treatment
What they're measuring
1
The erosion area of oral lichen planus
Timeframe: 3 months
Trial details
NCT IDNCT06498180
SponsorShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University