Differential Thrombogenesis by EPA and DHA Mediated by HDL

Inclusion Criteria: * Fasting TG levels ≥ 150 mg/dL and \< 500 mg/dL and HDL-C ≤ 40 (men) or ≤ 50 (women) * LDL-C \> 40 mg/dL and ≤ 130 mg/dL * Able to provide informed consent and adhere to study schedules * Agree to follow and maintain a relatively stable and low fatty fish intake diet (\<3 servings per week) Exclusion Criteria: * Female with pregnancy, planned pregnancy (within the study period), or currently breastfeeding. * Subjects with weight changes greater than 20% over the past 3 months * Subjects planning a significant change in diet or exercise levels * Malabsorption syndrome and/or chronic diarrhea * Use of dietary supplements containing n-3 PUFA fatty acids * Frequent consumption of n-3 PUFA-enriched fish (\>3 times a week) * Abnormal liver, kidney, or thyroid functions * Drug or alcohol abuse within 6 months or significant mental/psychological impairment * Current smokers * Subjects taking daily aspirin, NSAIDs, anticoagulant, or corticosteroids * Subjects with known bleeding disorders (for example, hemophilia) * Known sensitivity or allergy to fish, shellfish, or omega-3 fatty acid supplements * Subjects requiring regular transfusions for any reason * No ethnic/racial groups will be excluded