Currently, 40% of global dementia cases can be prevented through lifestyle changes, with Latin America having a 56% potential reduction due to its high-risk factors. At the moment, there are no medications that halt the clinical expression of dementia.
LatAm-FINGERS, a multicenter study across 12 Latin American countries, aims to study the feasibility of an intervention modifying lifestyle in individuals aged 60 to 77 at risk of dementia. Success could influence public policy on clinical care for older adults.
Who can participate
Age range60 Years – 77 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* Age: 60-77 years.
* Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) Risk Score \> 6.
* Mini-Mental State Examination (MMSE) z score between 0 and -1.5 OR
* CERAD Word List Learning Task (10 word x 3 repetitions) \< 0 z score OR
* CERAD (delayed word list recall) \< z score \< 0
Exclusion Criteria
* MMSE \< 20
* Dementia
* Any medical condition that affects the participant's safety.
* Severe osteoarticular problems that preclude the implementation of the physical activity intervention outlined in the protocol, such as, for example: osteoarthrosis of the knee(s), coxofemoral, or other.
* Significant neurological disease, including dementia, cognitive impairment, Parkinson's disease, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis or history of significant head injury with persistent neurological sequelae or structural brain abnormalities, major depressive disorder within the last 2 months, history of bipolar disorder or schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders V (DSM V) criteria.
* Severe cardiovascular disease, including heart failure, clinically significant aortic stenosis, history of uncontrolled acute myocardial infarction (AMI) or angina and Cardiac rhythm disorders: g3 conduction block, uncontrolled arrhythmia, alterations in Q wave, S waver and T wave segment or QT segment and auric…
What they're measuring
1
Reach
Timeframe: Up to 2 years
2
Implementation
Timeframe: Up to 2 years
3
Maintenance
Timeframe: Up to 2 years
Trial details
NCT IDNCT06492967
SponsorFundación para la Lucha contra las Enfermedades Neurológicas de la Infancia