A Study of BGB-R046 as Monotherapy and in Combination With Tislelizumab in Solid Tumors

Inclusion Criteria: * Participants able to provide a signed and dated written informed consent prior to any study-specific procedures, sampling, or data collection * Participants with histologically or cytologically confirmed advanced, metastatic, and unresectable solid tumors who have previously received standard systemic therapy or for whom standard treatment is not available, not tolerated, or determined not appropriate based on the investigator's judgement * ≥ 1 measurable lesion per RECIST v1.1 * Able to provide an archived tumor tissue sample * Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 1 * Adequate organ function * Life expectancy \>12 weeks as determined by the investigator Exclusion Criteria: * Active leptomeningeal disease or uncontrolled, untreated brain metastasis * Active autoimmune diseases or history of autoimmune diseases that may relapse * Any malignancy ≤ 3 years before the first dose of study drug(s) except for the specific cancer under investigation in this study and any locally recurring cancer that has been treated with curative intent (eg, resected basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix or breast) * Any condition that required systemic treatment with either corticosteroids (\> 10 mg daily of prednisone or equivalent) or other immunosuppressive medication ≤ 14 days before the first dose of study drug(s) * History of interstitial lung disease, noninfectious pneumonitis (inc…