This phase I trial tests the safety, side effects, best dose of MUC1-activated T cells in treating patients with ovarian cancer that has come back after a period of improvement (relapsed) or that remains despite treatment (resistant). T cells are infection fighting blood cells that can kill tumor cells. The T cells given in this study will come from the patient and are made in a laboratory to recognize MUC1, a protein on the surface of tumor cells that plays a key role in tumor cell growth. These MUC1-activated T cells may help the body's immune system identify and kill MUC1 expressing ovarian tumor cells.
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Dose-limiting toxicities (DLT)
Timeframe: Up to 28 days after T cell infusion
Maximum tolerated dose (MTD)
Timeframe: Up to 28 days after T cell infusion
Objective response rate
Timeframe: Up to 2 years