Correlation of Portal and Peripheral Venous ctDNA in Pancreatic Adenocarcinoma

Inclusion Criteria: * Age ≥ 18 years * Patient with operable pancreatic adenocarcinoma (resectable or boderline with or without neoadjuvant therapy) with histological evidence or indirect diagnostic criteria (CA 19-9 Significant (≥ 200 U/ml), pancreatic hypodense lesion without differential diagnosis) * Biological criteria: Neutrophils \> 1,500 cmm, platelet count \> 100,000 cmm, creatinine clearance (Cockroft and Gault equation) \> 60 ml/min, hemoglobin \> 10 g/dl. * ECOG performance status 0 or 1 * Patient has read and understood the information letter and signed the non-opposition/consent form. * For an adult unable to give consent: Representative of the adult who has read and understood the information letter and signed the consent form Exclusion Criteria: * Other active cancer or haematological malignancy * Uncontrolled congestive heart failure - untreated angina pectoris; recent myocardial infarction (within the last year) - uncontrolled hypertension (SBP \> 160 mm or DBP \> 100 mm, despite optimal drug therapy), long QT. * Uncontrolled major infections, chronic infectious diseases, immunodeficiency syndromes * Premalignant hematological disorders, e.g. myelodysplastic syndrome * Severe hepatic impairment * Patients not registered with social security * Pregnant, parturient or breast-feeding woman (a pregnancy test will be carried out unless there is a history of hysterectomy, tubal ligation or menopause) * Person deprived of liberty by an administrative or judicial …