A Study of Sacituzumab Govitecan in People With Mesothelioma

Inclusion Criteria: * Patient, or legally authorized representative (LAR), willing and able to provide written informed consent for the trial * Patient age ≥ 18 at time of consent * Pathologically confirmed diffuse pleural mesothelioma * Must have received at least one prior systemic therapy (platinum/pemetrexed, immunotherapy or a combination thereof) * Measurable disease as defined primarily by the modified RECIST criteria for mesothelioma (at PI discretion RECIST v1.1 may be used) * Consent to undergo a biopsy prior to Cycle 1 Day 1 and Cycle 3 Day 1 if deemed medically safe and feasible * Eastern Cooperative Oncology Group (ECOG) score 0 or Karnofsky Performance Status ≥ 70% * Adequate organ function, defined as * Absolute neutrophil count ≥ 1.5K/mcL * Platelet count ≥ 100K/mcL * Adequate renal function defined as creatinine clearance ≥ 30ml/min (as calculated by Cockcroft-Gault Formula) * Hemoglobin \> 9g/dL (prior transfusion permitted if not within 7 days of enrollment) * Total bilirubin ≤1.5 x upper limit of normal (ULN) if no liver metastases or \<3 × ULN in the presence of documented Gilbert's Syndrome (unconjugated hyperbilirubinemia) or liver metastases; subjects with Gilbert's syndrome can enroll if conjugated bilirubin is within normal limits * AST, ALT ≤ 2.5 x ULN (if liver metastases are present, ≤5 × ULN) * If of childbearing potential, must be willing to use highly effective mode of contraception for at least one month prior, during, and for 2 …