Not Yet RecruitingPhase 4

Multicenter Study of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia

356 participantsStarted 2024-06-18

Plain-language summary

Women requiring epidural labor analgesia were randomized into two groups, one with the local anesthetic chloroprocaine and the other with ropivacaine. The primary outcome was to observe the analgesic scores of the two groups of drugs as well as adverse reactions.

Who can participate

Age range20 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Primigravid women with full-term pregnancies scheduled for labor analgesia * Determination of labor onset to cervical dilatation ≤ 5cm; * Visual analogue scale (VAS) pain score during contractions \>50 mm (0 mm = no pain at all, 100 mm = most intense pain); * Age ≥20 years; * American Society of Anesthesiologists (ASA) classification II * Body mass index (BMI) between 18.5 and 30 kg/m2 * Height \>155 cm * Signed informed consent. Exclusion Criteria: * Twin or multiple pregnancies * Hypertension * Severe cardiopulmonary and hepatic or renal disease * Severe pregnancy comorbidities such as preeclampsia, eclampsia, HELLP syndrome, placenta praevia, placental abruption, etc. * Cephalopelvic disproportion * History of allergy to local anesthesia * Spinal deformity * Contraindications to intrathecal anesthesia * Refusal to participate in the stud

What they're measuring

Percentage of effective analgesia

Timeframe: 30 min after the first epidural addition at the beginning of labor analgesia

Trial details

NCT IDNCT06472232

SponsorWomen's Hospital School Of Medicine Zhejiang University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-16

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