UFPTI 2403-PR12: Real-Time Volumetric Ionizing Radiation Acoustic Imaging for In-vivo Proton Treatment Monitoring in Pencil-Beam Scanning

Inclusion Criteria: * Disease: Prostate cancer * Treatment site: * Prostate or prostate and seminal vesicle * No regional lymph node is involved * Patient's body weight: Patient's body weight is less than 350 lbs to consider the total weight limit that the ProteusONE treatment table and the robotic arm can operate * Treatment volume size: maximum size less than 15 x 15 cm in a cross-section and a thickness less than 20 cm to consider 2D transducer matrix size * Provision to sign the consent form and understand the non-invasiveness of iRAI * Patient agreement on tolerance on placing a water bag to acquire iRAI during treatment * Treatment modality: Proton radiation therapy with UFHPTI's ProteusONE gantry using PBS Exclusion Criteria: * A patient who would not be tolerable or will feel nervous about being touched on the skin with a water bag * A patient with a significant medical implant or hardware in the treatment area