The purpose of this study is to find out whether the study drug, LY4052031, is safe, tolerable and effective in participants with advanced, or metastatic solid tumors including urothelial cancer. The study is conducted in two parts - phase Ia (dose-escalation, dose-optimization) and phase Ib (dose-expansion). The study will last up to approximately 4 years.
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Phase 1a: To determine the recommended phase 2 dose (RP2D) optimal dose(s) of LY4052031
Timeframe: Cycle 1 (21 Days)
Phase 1b: To assess the antitumor activity of LY4052031 Monotherapy: Overall response rate (ORR)
Timeframe: Up to Approximately 48 Months or 4 Years
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or