CompletedNot Applicable

Opioid-based Versus Opioid-free Endotracheal Intubation

Greece70 participantsStarted 2024-03-20

Plain-language summary

The aim of this study will be to investigate the effect of opioid-free induction versus opioid-based induction on hemodynamic response and nociception level index during elective operations

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * adult patients * American Society of Anesthesiologists (ASA) classification I-II * Mallampati classification 1, 2 or 3 Exclusion Criteria: * anticipated difficult airway (Mallampati 4 classification, thyromental distance \< 6 cm, mouth opening \< 3 cm, neck extension\< 80 * atrioventricular block * bradycardia (heart rate less than 55/min) * preadministration of beta-blockers * eligibility for rapid-sequence induction * chronic use of opioid medications * known allergy to induction agents * history of psychiatric disease * language or communication barriers or lack of informed consent

What they're measuring

change from baseline in systolic arterial pressure after premedication

Timeframe: 30 seconds after premedication

change from baseline in systolic arterial pressure immediately after premedication

Timeframe: immediately after intubation

change from baseline in systolic arterial pressure 1 minute after intubation

Timeframe: 1 minute after intubation

change from baseline in systolic arterial pressure 3 minutes after intubation

Timeframe: 3 minutes after intubation

change from baseline in systolic arterial pressure 5 minutes after intubation

Timeframe: 5 minutes after intubation

change from baseline in diastolic arterial pressure after premedication

Timeframe: 30 seconds after premedication

change from baseline in diastolic arterial pressure 1 minute after intubation

Timeframe: 1 minute after intubation

Trial details

NCT IDNCT06464393

SponsorAretaieion University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-20

View on ClinicalTrials.gov More Anesthesia trials

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

change from baseline in systolic arterial pressure after premedication

Timeframe: 30 seconds after premedication

change from baseline in systolic arterial pressure immediately after premedication

Timeframe: immediately after intubation

change from baseline in systolic arterial pressure 1 minute after intubation

Timeframe: 1 minute after intubation

change from baseline in systolic arterial pressure 3 minutes after intubation

Timeframe: 3 minutes after intubation

change from baseline in systolic arterial pressure 5 minutes after intubation

Timeframe: 5 minutes after intubation

change from baseline in diastolic arterial pressure after premedication

Timeframe: 30 seconds after premedication

change from baseline in diastolic arterial pressure 1 minute after intubation

Timeframe: 1 minute after intubation