CompletedNot Applicable

Dobutamine for Management of Surgical Patients With Septic Shock

China584 participantsStarted 2024-06-18

Plain-language summary

Septic shock is the last and most severe stage of sepsis and is defined by extremely low blood pressure, despite lots of intravenous fluids. The incidence of septic shock related cardiomyopathy was 10% to 70%. Besides, general anesthesia will inhibit the sympathetic nervous system, reduce myocardial contractility and aggravate cardiac dysfunction. No randomized controlled trials have yet explore the effects of dobutamine on clinical outcomes for patients with septic shock undergoing surgery under general anesthesia.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Patients with 18 years or older
✓. Sugery patients with septic shock and the duration of opration is more than 1 hour

Exclusion criteria

✕. Pregnancy;
✕. Long-term intakeβ-receptor blocker;
✕. patietns with dobutamine used within 72h before enrollment;
✕. Patients use Recombinant Human Brain Natriuretic Peptide(rhBNP), Levosimendan and Epinephrine within 72h before enrollment;
✕. Patients with hyperthyroidism;
✕. Allergy or known sensitivity to catecholamines（norepinephrine, dobutamine etc.）and genera anesthetics.
✕. Patients and guardians refused to participate in this intervention clinical trial.

What they're measuring

Incidence of acute kidney injury after surgery

Timeframe: within 1 week after surgery

Sequential Organ Failure Assessment (SOFA) score

Timeframe: Day 1 Day 3 and Day 7 in ICU after surgery

Mortality

Timeframe: in hospital and Day 28 and Day 90 after the surgery

Trial details

NCT IDNCT06462313

SponsorFirst Affiliated Hospital of Zhejiang University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-15

View on ClinicalTrials.gov More Patients With Septic Shock trials