Packed Red Blood Cell Transfusion During Cardiac Arrest

Inclusion Criteria: * Adult patients, age ≥18 and \<85 years * Experience prolonged, non-trauma-related in-hospital cardiac arrest, defined by cessation of heartbeat and respiration requiring CPR for at least 10 minutes Exclusion Criteria: * Age \<18 years old * Age \> 85 years old * Patients with DNR/DNI orders (Do Not Resuscitate/Do Not Intubate) * Patients admitted to the hospital with a cardiac arrest arising from trauma * Patients who achieve return of spontaneous circulation within 10 minutes of CPR * Inability to start study product administration within 20 minutes of cardiac arrest onset * Prisoners * Women who are known to be pregnant * Patients with a history of RBC antibodies or positive antibody screen prior to enrollment in the study, unless previously cross-matched units are available for transfusion. * Patients with ultrasound evidence of right ventricular dilatation at time of CA * Patients with known prior objection to receipt of blood products. * Patients for whom administration of additional fluid volume is contraindicated (as determined by physician responsible for care) * Physician objection based on concern that intervention would interfere with patient care plan