By InvitationNot Applicable

Exploring Pathology Related to Slowly Expanding Lesions Using Advanced Imaging

Finland15 participantsStarted 2024-10-03

Plain-language summary

This is an open, follow-up study to compare the performance of three critical imaging methods to detect chronic active lesions in Multiple Sclerosis (MS) in vivo.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Signing the informed consent form * MS diagnosis in accordance with McDonald 2017 criteria * Available longitudinal brain MR images (minimum 1 year) * Simultaneous QSM MRI sequence and TSPO-PET * Lesions with iron rim/s Exclusion Criteria: * Patients with other neurodegenerative disease than MS * Patients with other autoimmune disease than MS * Patients with other significant or malignant underlying disease of any other organ system * Patients that are pregnant or breast-feeding * Corticosteroid treatment within 4 weeks of imaging * Patients with significant abnormal findings other than MS in the screening MRI * Patients with claustrophobia, or a history of moderate to severe anxiety disorder or panic attacks (which could potentially lead to preterm termination of the imaging) * Contraindication to PET scan investigations * Exposure to experimental radiation in the past 12 months such that radiodosimetry limits would be exceeded by participating in this study * Intolerance to previous PET scans; i.e. previous hypersensitivity reactions to any PET ligand or imaging agent or failure to participate in and comply with previous PET scans

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Number of lesions

Timeframe: 18 months, 36 months

Co-localization of lesions

Timeframe: 18 months, 36 months

Trial details

NCT IDNCT06460077

SponsorTurku University Hospital

Sponsor typeOTHER_GOV

Study typeOBSERVATIONAL

Primary completion2028-06

View on ClinicalTrials.gov More Multiple Sclerosis trials

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.