Effects of the Application of a Hyper-oxygenated Gel After Oral Surgery

Inclusion Criteria: * good systemic and local health conditions of the patient; * age between 18 and 35 years; * understanding of the Italian language, * indications for the extraction of impacted bilateral lower third molars (38 and 48) according to the criteria reported in the classifications of Winter and that of Pell and Gregory; * the root of the impacted third molars is completely formed. Exclusion Criteria: * diabetes mellitus; * systemic arterial hypertension; * hyperthyroidism; * osteoporosis; * immunosuppressed; * osteonecrosis of the jaws; * pregnancy; * patients with mandibular third molars in position C according to "the Pell \& Gregory Classification" on the radiological measurements (angles and positions) for which third molar extraction surgery is required.; * local alterations such as pericoronitis, odontogenic cysts and tumors in relation to the third molars; * allergies; * ordinary use of analgesics or antibiotics by the patient.