Invasive Candidiasis in Critical Care

Inclusion Criteria: * critically ill patients * new onset sepsis * rise in body temperature \>38°C according to The Third Consensus Definitions for Sepsis and Septic Shock * colonization with Candida spp. from more than 1 non-sterile site * body temperature \>38 °C despite 5 days of broad-spectrum antibiotic therapy with the presence of at least 1 of the following risk factors: abdominal surgery, secondary peritonitis, pancreatitis, central venous catheter (CVC) insertion, total parenteral nutrition (CPV), dialysis, steroid therapy, immunosuppressive therapy, or liver transplantation * microbiological test results will be reviewed and categorized based on whether Candida sp. is isolated from at least 2 non-sterile sites (±3 days) and whether there is an alternative microbiological diagnosis. Exclusion Criteria: * not signing the informed consent with participation in the study * administration of antifungal therapy prior to collection of the biological material required for the study