The purpose of this pilot interventional study is to collect preliminary data on administering magnesium sulfate as a neuroprotective medication in patients who achieved Return of Spontaneous Circulation (ROSC) following Cardiac Arrest (CA). The primary aims are to assess the feasibility and safety of administering magnesium and measure serum markers of neuronal injury at prespecified time points in the post-cardiac arrest period. Because this is a pilot study with a limited sample size, the primary objective is to evaluate the precision and stability of the collected measures to inform the design and formal analysis in a larger trial.
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Proportion of cases where successful randomization occurred
Timeframe: Through study completion, an average of 90 days
Proportion of cases where Magnesium (Mg) or saline bolus was delivered with a goal of <2 h after return of spontaneous circulation (ROSC)
Timeframe: Through study completion, an average of 90 days
Proportion of cases with adherence to treatment protocol
Timeframe: Through study completion, an average of 90 days
Proportion of cases for which serum is successfully drawn and analyzed
Timeframe: Through study completion, an average of 90 days
Proportion of cases where patient's Cerebral Performance Category Score (CPC) status is assessed
Timeframe: At hospital discharge, on average 3 weeks
Proportion of cases where patient's CPC status is assessed
Timeframe: Day 30
Proportion of cases where patient's CPC status is assessed
Timeframe: Day 90