Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis))

Inclusion Criteria: * Adult Patients, ≥18 years old. * Who are prescribed antibiotic therapy (as per medical routine practices, amoxicillin 1000 mg bid for 14 days) in the context of erythema migrans (early skin form of Lyme borreliosis). * Able to comply with study requirements and to provide signed informed consent before any study procedure. * Has no condition that may interfere with the study assessments. * Able to fulfil in the diary stool log, according to the physician's opinion. * Regular defecation (frequency and stool consistency, with at least about three bowel movements a week). * For women of childbearing potential: * A negative urine pregnancy test immediately prior to starting the study treatment, * Agreement to comply with approved methods of contraception during the whole study: unless they meet the criteria of post-menopausal, i.e. 12 months of spontaneous amenorrhea, women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, including women whose career, lifestyle, or sexual orientation precludes intercourse with a male partner, should use one or more acceptable methods of contraception that should be maintained throughout the study. Exclusion Criteria: * History of hypersensitivity to the study treatments (active substance or excipients), brewer's or baker's yeast, * Contraindication and special warning to the study drugs according to the SmPCs, * History of chronic constipation with passage of fewer than 3 spon…