Cannabidiol After Multi-Trauma for Pain and Opioid Therapy

Inclusion Criteria: * Patients with a long bone fracture of the lower limb (tibia, fibula, femur, metatarsals, and phalanges) or the upper limb (humerus, radius, ulna, metacarpals, and phalanges) treated to Sacre-Coeur Hospital in Montreal (HSCM) within one week of the accident * Participants is between 18 and 70 years of age * Patients with or without surgical procedures Exclusion Criteria: * Moderate/severe traumatic brain injury (TBI) * Diagnosis of any of the following mental disorders as defined by the DSM-5: schizophrenia, intellectual disability, bipolar disorder, major depression, a diagnosed and untreated sleep disorders * History of alcohol or opioid misuse/abuse, as defined by the DSM-5 * Evidence of severe renal (stage 4 or 5) or hepatic impairment (Child B or C) * Pregnant or lactating women, women of childbearing potential who are not using medically accepted forms of contraception (e.g., condoms, oral contraceptive or intrauterine device), or women who are actively planning on becoming pregnant * History of adverse reactions to cannabis * Patients taking warfarin, sildenafil, valproate or under opioids treatment prior to the injury * Patients experiencing on average mild-to-absent pain in the last 24h preceding recruitment (as per a score \<30 on a 0-100mm Visual Analogue Scale (VAS)) * Transport business drivers and heavy machinery operators * A diagnosis of chronic pain, bone pathology (e.g., osteoporosis) or chronic inflammatory disease (e.g., rheumatoid …