The main purpose of this study is to see how much of orforglipron (study drug) gets into the bloodstream and how long it takes the body to get rid of it when given as capsules compared to tablets in healthy overweight and obese participants. The safety and tolerability (side effects) of orforglipron when given as capsules and tablets will also be evaluated. The study will be conducted in two parts, with part A and B lasting up to approximately 25 and 22 weeks each respectively, including the screening period.
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Part B: Pharmacokinetics (PK): Steady-state area under the concentration versus time curve from time 0 to Ï„ hour time point AUC(0-Ï„) of Orforglipron capsule at test dose levels 2,3,4 and 6 along with the corresponding tablet dose strengths
Timeframe: Day 1 up to Week 9 (Cohort 1), Week 15 (Cohort 2)
Part B: PK: Steady-state Maximum Observed Concentration (Cmax) of Orforglipron capsule at test dose levels 2,3,4 and 6 along with the corresponding tablet dose strengths
Timeframe: Day 1 up to Week 9 (Cohort 1), Week 15 (Cohort 2)