Transcranial Direct Current Stimulation for Treatment of Acute Ischemic Stroke

Inclusion Criteria: * New focal neurologic deficit consistent with AIS * National Institute of Health Stroke Scale (NIHSS) ≥4 or NIHSS\< 4 in the presence of disabling deficit (a deficit that, if unchanged, would prevent the * patient from performing basic activities of daily living such as bathing, ambulating, toileting, hygiene, and eating or returning to work) * Age\>18 * Presence of any cortical vessel occlusion, including Internal Carotid Artery, branches of Middle Cerebral Artery, Anterior Cerebral Artery, Posterior Cerebral Artery, Posterior-Inferior Cerebellar Artery * Presence of salvageable penumbra with perfusion lesion volume to ischemic core volume ratio of ≥ 1.2 on multimodal imaging * Patient ineligible for endovascular thrombectomy per American Heart/Stroke Associations Guidelines * Patient is able to be treated with tDCS within 24 hours of last known well time * A signed informed consent is obtained from the patient or patient's legally authorized representative Additional inclusion criteria for non-thrombolytic patients • Patient ineligible for IV lytics per American Heart/American Stroke Associations National Guidelines Additional inclusion criteria for thrombolytic receiving patients * Patient eligible for tPA per Guidelines * Within 2-hours from intravenous thrombolytic start of administration Exclusion Criteria: * Acute intracranial hemorrhage * Presence of MRI and gadolinium contraindications including cardiac implantable devices, cochlear implan…