Colchicine to Quench the Inflammatory Response After Deep Vein Thrombosis (The Conquer-DVT Pilot Trial)

Exclusion criteria

• ✕. History of an allergic reaction or significant sensitivity to colchicine.
• ✕. Requirement of colchicine for other indications.
• ✕. Active or chronic diarrhea, or documented inflammatory bowel disease (i.e., Crohn's disease or ulcerative colitis), collagenous colitis or irritable bowel syndrome or existing blood dyscrasias.
• ✕. Known or suspected, recent (\<30 days) or active infections (acute or chronic).
• ✕. History of cirrhosis, chronic active hepatitis, or severe liver disease.
• ✕. Recent (\<30 days) or chronic use of systemic (oral, intravenous) immunosuppressive drugs (including but not limited to steroids, tumor necrosis factor-alpha blockers, cyclosporine).
• ✕. Known active cancer.
• ✕. Any of the following as measured within the past 1-3 months or at screening: alanine, or aspartate aminotransferase \>3 times the upper limit of normal, total bilirubin \>2 times the upper limit of normal and a creatinine clearance by Cockcroft-Gault formula \<30 mL/min.