Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients (NCT06438302) | Clinical Trial Compass
RecruitingNot Applicable
Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients
France22 participantsStarted 2025-01-31
Plain-language summary
The passage of air through the nasal cavity generates rhythmic oscillations transmitted by the olfactory bulb to the brain, which induces cerebral activation in functional areas and is associated with better cognitive performance compared to oral breathing. Consequently, the abolition of nasal ventilation in patients intubated via the orotracheal route could have deleterious effects on brain activity. Besides the loss of olfaction, the abolition of nasal ventilation could affect brain activity and respiratory control, consequently altering regional pulmonary ventilation.
The hypothesis of the study is that nasal ventilation through the passage of humidified nasal airflow in patients intubated via the orotracheal route would be associated with modulation of cerebral electrical activity and tissue oxygenation and a modification of regional pulmonary ventilation.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age ≥ 18 years old
✓. Hypoxemic acute respiratory failure
✓. Intubation and mechanical ventilation since less than 4 days
✓. PaO2/FiO2 ratio less than 200
✓. RASS\<-4
✓. Consent obtained from next of kin
✓. Patient with health insurance
Exclusion criteria
✕. Central nervous system diseases (stroke, MS, epilepsy)
✕. Psychiatric illnesses (psychosis, depression) (indicated on patient's medical record)
✕. Patients under legal protection (guardianship/curators)
What they're measuring
1
Study the effects of nasal ventilation on brain electrical activity using electroencephalogram recording (EEG) in sedated orotracheally intubated patients.