The Effect of Omega 3 Supplementation on Postoperative Delirium in Elderly Patients Undergoing Major Cardiac Surgery

Inclusion Criteria: * Age ≥ 65 years * American Society of Anesthesiologists (ASA) Class Physical Status I-IV Exclusion Criteria: * Inability to obtain written informed consent. * Inability to take study drug due to intubation or other reason. * Delirium present at screening. * Known hypersensitivity (e.g. anaphylactic reaction) to omega-3 ethyl esters or any of its components * Allergy to fish or shellfish * Currently taking warfarin (Coumadin), apixaban (Eliquis), dabigatran (Pradaxa), edoxaban (Savaysa/Lixiana), rivaroxaban (Xarelto), or other anticoagulant drugs. * Currently taking omega-3, omega-6, vitamin E, or fish oil supplements. * Significant renal disease with a serum creatinine ≥ 2 mg/dL. * Significant liver disease with alanine aminotransferase (ALT) levels 1.5 times the normal range of 6-45 units/liter and aspartate transferase (AST) levels 1.5 times the normal range of 10-42 units/liter. * History or diagnosis of diabetes. * History or diagnosis of neurodegenerative disease such as Parkinson's, Alzheimer's, or dementia. * History or diagnosis of bleeding disorder. * History or diagnosis of metabolic syndrome or disorder. * History or diagnosis of thyroid problems such as hyperthyroidism or hypothyroidism.