The objective of this study is to assess the pharmacokinetics (PK) and absolute bioavailability of BMS-986365 and to investigate the PK, metabolite profile, routes and extent of elimination, and mass balance of BMS-986365.
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Maximum observed concentration (Cmax)
Timeframe: Up to Day 60
Time of maximum observed concentration (Tmax)
Timeframe: Up to Day 60
Area under the plasma concentration-time curve from time zero to time of last quantifiable concentration (AUC(0-T))
Timeframe: Up to Day 60
Area under the plasma concentration-time curve from time zero extrapolated to infinite time (AUC (INF))
Timeframe: Up to Day 60
Apparent terminal plasma half-life (T-HALF)
Timeframe: Up to Day 60
Total body clearance (CLT)
Timeframe: Up to Day 15
Apparent total body clearance (CLT/F)
Timeframe: Up to Day 60
Mean residence time (MRT)
Timeframe: Up to Day 15
Apparent volume of distribution (Vz)
Timeframe: Up to Day 15
Apparent volume of distribution (Vz/F)
Timeframe: Up to Day 60
Absolute bioavailability (F)
Timeframe: Up to Day 15