CompletedNot Applicable

Clinical and Microbiological Evaluation of Laser Therapy in the Treatment of Periodontal Disease in Stages III and IV

Brazil20 participantsStarted 2024-05-06

Plain-language summary

The aim of this clinical trial is to evaluate photodynamic therapy and photobiomodulation in the periodontitis treatment. To evaluate the clinical and microbiological response of conventional periodontal treatment associated with photodynamic therapy and photobiomodulation with red or infrared laser. Participants will receive periodontal treatment carried out with the use 0.005% methylene blue and laser therapy (photodynamic therapy), associated with conventional periodontal treatment, as well as the use of photobiomodulation with red or infrared laser associated with conventional periodontal treatment in participants with periodontitis. So, twenty periodontitis patients will be selected and separated in two groups compared with placebo. Clinical and microbiological parameters will be evaluated at baseline and 3 months after periodontal treatment: plaque Index, bleeding on probe, probing depth, gingival recession and clinical attachment level.

Who can participate

Age range18 Years – 70 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult participants with periodontal disease; * Four or more periodontal sites with PPD≥6 mm and CAL≥5 mm, non-adjacent; * Generalized periodontitis, with more than 30% of the sites involved (Caton et al., 2018); * Stages III and IV of periodontal disease (Caton et al., 2018); Exclusion Criteria: * Participants with hypersensitivity to the components of the 0.005% methylene blue gel; * Received periodontal treatment in the last six months; * Drugs (alcoholics, use of anti-inflammatories and antibiotics in the last 3 months); Any evidence of systemic modifying factors which may directly interfere with the completion of the work (bias), such as: * Pregnant and breastfeeding women; * Hormone replacement therapy; * Smoking; * Hyperglycemia; * Osteoporosis; * Diagnosed with HIV+ or AIDS.