Tobacco, Alcohol and Cancerization of the Oral Mucosa (TACO)

Inclusion Criteria: * I1. Male or female aged 18 years or older at the date of signature of the informed consent to participate. * I2. Patient with histological diagnosis of epidermoid carcinomas of the oral cavity NB: All grades are eligible. * I3. Patient naive of any systemic anti-cancer treatment (radio- or chemotherapy). * I4. Patient able to understand, sign and date informed consent before the start of any study protocol procedure. * I5. Patient affiliated or covered by a medical insurance Exclusion Criteria: * E1. Patients at high risk of bleeding, such as those on anticoagulant or antiplatelet aggregant treatment, with clotting disorders or a history of severe bleeding in the two weeks prior to inclusion. * E2. Patient with lesions of all types on the mucosa of the cheek located on the opposite side of the area affected by an epidermoid carcinoma of the oral cavity which prevents painless removal of the healthy mucosa. * E3. Patient who had surgery for their epidermoid carcinoma of the oral cavity more than 6 months ago. * E4. Patient who uses cannabis. * E5. Patient with another active tumor or HPV-positive tumors. * E6. Patient under guardianship or curatorship or placed under the protection of justice. * E7. Pregnant and/or nursing patient.