RecruitingNot Applicable

Autopsy and Photon Counting Computed Tomography to Evaluate Thromboses Related to Central Venous Catheters

Sweden75 participantsStarted 2025-01-16

Plain-language summary

Central venous (CVC) is essential in modern healthcare but unfortunately associated with complications, including thrombosis. In a recently published study, it was showed that 12 out of 12 deceased patients had subclinical CVK-related thrombosis (Rockholt et al.). To shed light on this problem, the current studies were designed. In sub-study 1, deceased patients with CVC who are referred for clinical autopsy are included. Before the autopsy, the deceased will be examined with a photon-counting computed tomography (CT) scan and the results will be compared. In sub-study 2, living patients with CVC who are referred for various CT scans without contrast, are included. After informed consent, the patient will be examined with the photon-counting CT, whose reliability has been validated in Part 1 and the incidence of subclinical CVC-related thrombosis will be reported.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Substudy 1 Inclusion Criteria: * Diseased patients with an indwelling central venous catheter and a clinical indication for autopsy * Informed and signed consent from next of kind Exclusion Criteria: * None Substudy 2 Inclusion Criteria * Living patients with an indwelling central venous catheter who are referred to a CT scan without iv contrast * Informed and signed consent from the patient Exclusion Criteria \- GFR \<15 mL/min/1.73 m2

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The incidence of venous thrombosis related to a central venous catheter in diseased patients

Timeframe: At autopsy

The performance of the photon counting CT on diseased patients

Timeframe: After death. The CT scan and the autopsy will be performed within 1 week after death

The incidence of venous thrombosis related to a central venous catheter in living patients

Timeframe: At CT scan

The performance of ultrasound compared to the photon counting CT

Timeframe: Ultrasound will be performed ±24 hours from the CT

Trial details

NCT IDNCT06417541

SponsorThomas Kander

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-06

Contact for this trial

Thomas Kander, PhD

+4646171163 thomas.kander@med.lu.se

View on ClinicalTrials.gov More Central Venous Catheter Thrombosis trials