This study is aimed to evaluate outpatient ketamine infusion within a military chronic neuropathic pain population and its effect on PTSD. Currently, this is a pilot study with 30 participants. Participants will be randomized to (1) a moderate dose ketamine, (2) moderate dose ketamine +Mg, or (3) a magnesium control group. Participants will complete self-reported pain and PTSD questionnaires throughout the \~24-week study period. The outlined strategy will provide evidence for the utility of ketamine in neuropathic pain management and pain associated comorbidities within a military population.
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Defense and Veterans Pain Rating Score (DVPRS)
Timeframe: Up to 32 weeks
Brief Pain Inventory Scale (BPI)
Timeframe: Up to 32 weeks
Life Satisfaction Questionnaire (LiSAT)
Timeframe: Up to 32 weeks
Post-traumatic Stress Disorder Checklist (PCL-5)
Timeframe: Up to 32 weeks
The Patient-Reported Outcomes Measurement Information System (PROMIS 29+2)
Timeframe: Up to 32 weeks
Patient Health Questionnaire-9 (PHQ-9)
Timeframe: Up to 32 weeks
Generalized Anxiety Disorder Scale
Timeframe: Up to 32 weeks