VIsualization of Coronary Artery Disease for Modification of RISK Factors (NCT06413641) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
VIsualization of Coronary Artery Disease for Modification of RISK Factors
Denmark273 participantsStarted 2024-03-12
Plain-language summary
The VICAD-RISK study assesses if visualization of coronary CT angiography (CTA) images in participants with non-obstructive coronary artery disease will improve LDL lowering, reduce reporting of side effects by cholesterol lowering medications, and modify the coronary artery disease phenotype over 12 months.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* New diagnosis of nonobstructive coronary artery disease
* No known coronary artery disease (no previous coronary revascularization)
* Coronary Artery Disease Reporting and Data System (CAD-RADS) score 1-3
* LDL cholesterol \> 2.0 mmol/l
* Life expectancy \>3 years
* Signed informed consent
Exclusion Criteria:
* Post CTA test indication for invasive coronary angiography
* Non-evaluable CTA exam
* Obstructive coronary disease (One or more coronary stenosis ≥70%, left main \>40%)
* Ongoing lipid lowering medical treatment (Patients already on lipid lowering medical therapy can be included if the treatment was initiated \<3 months before the time of the CTA test)
* BMI \>40
* Renal insufficiency (eGFR \<40 ml/min)
* Allergy to iodinated contrast media
* Contraindications to statins (Active liver disease Child-Pugh A, B and C, excessive alcohol consumption)
* Participation in a cardiac rehabilitation or lifestyle modification program
* Pregnancy