ColoSeal™ ICD System Safety and Feasibility Study

Inclusion Criteria: * Subject is 18-65 years of age at screening, or subject is 66-70 years of age at screening with up to one cardiovascular, metabolic or pulmonary comorbidity for which medication is prescribed. * Subject is diagnosed with rectosigmoid or rectal cancer * Subject is scheduled for elective resection, either open, laparoscopic or robotic with mesorectal excision (either abdominal or transanal approach) which will require the creation of an anastomosis and protective ostomy (anastomosis maximally 15 cm from the anal verge). * The subject has been informed of the nature of the study, agrees to its provisions and has provided written informed consent, approved by the appropriate Medical Ethics Committee (EC) or Institutional Review Board (IRB). * Subject must be willing and able to comply with study follow-up requirements. Exclusion Criteria: * Subject with a life expectancy \< 1 year * Subjects with ASA classification \> 3 * Albumin \< 30 g/liter * Subject has local or systemic infection at the time of intervention. * Major surgical or interventional procedures within 30 days prior to this study or planned major surgical or interventional procedures within 1 month of entry into this study * Patient has received systemic chemotherapy or radiation to the pelvis within 30 days prior to the planned procedure * Subject has a diagnosis of bowel obstruction, bowel strangulation, peritonitis, bowel perforation, ischemic bowel, carcinomatosis, diverticulitis, or exten…