Sulfur vs. Different Regimes of Permethrin for Scabies (NCT06396507) | Clinical Trial Compass
CompletedPhase 3
Sulfur vs. Different Regimes of Permethrin for Scabies
Syria250 participantsStarted 2022-03-15
Plain-language summary
In 2017, the World Health Organization (WHO) labeled scabies as a neglected tropical disease. It is a serious health problem especially in poor developing countries like Syria, where overcrowding, poverty, and war consequences are considered major factors for spreading the disease. Permethrin lotion or cream is the treatment of choice for scabies, and it is applied once a week for two consecutive weeks according to the global guidelines. However, most practitioners in Syria do not adhere to this standard regimen, and a variety of regimens are used instead based mostly on clinical experience. In this study, the investigators are comparing four different regimens of permethrin application and comparing Sulfur to permethrin in terms of efficacy and safety.
Who can participate
Age range
2 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Scabies participants who meet "The 2020 International Alliance for the Control of Scabies (IACS) Consensus Criteria" level A or B.
* Participants can apply the treatment themselves or by their guardians if they are children.
* Participants willing to commit to the study's requirements
Exclusion Criteria:
* Participants are younger than two years.
* Participants with other skin diseases that could interfere with their assessment.
* Participants who received treatment for scabies in the preceding month.
* Receiving treatment with corticosteroids in the preceding week.
* Pregnancy, planning for pregnancy during the study, or breastfeeding.
* Systemic infection or receiving systemic therapy for an infectious disease
* Immunocompromised Participants.
* Participants with crusted/Norwegian scabies.
* Having sensitivity or allergy to permethrin or sulfur.
* Participants with abnormal liver and kidney functions, thyroid disease, cardiac disorders, psychiatric illnesses.
* Participation of a family member, or another member of the household in the current study.
* The number of participants' households is seven or more.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Clinical Recovery
Timeframe: At day 14 and 28 following the intervention.