Not Yet RecruitingNot Applicable

Midline Versus Dorsolateral Spinal Cord Stimulation for Post-surgical Neuropathic Pain

Canada40 participantsStarted 2025-09

Plain-language summary

The goal of this interventional study is to learn if dorsolateral spinal cord stimulation (DL-SCS) can treat focal post-surgical, medically refractory neuropathic pain. The main question it aims to answer is: \- How does DL-SCS compare to traditional SCS and no treatment for treating post-surgical neuropathic pain? Participants will be asked to * trial combinations of stimulation across blocks of weeks (randomized cross-over) * rate their pain after each stimulation trial

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Diagnosis of neuropathic pain following a surgical procedure
✓. A minimum of 50% of pain should be limited to one body part, defined as one limb or one side of trunk.
✓. Failed conservative therapies (medication, physiotherapy)
✓. Disability more than 6 months

Exclusion criteria

✕. Previous implantation with SCS (i.e. revision surgery)
✕. Any underlying condition that would preclude an MRI
✕. Untreated psychiatric conditions or substance use disorder
✕. Existing medical conditions that would preclude from SCS (history of recurrent infections, uncontrolled cancer, etc.)
✕. Surgically treatable lesion (e.g. spinal stenosis, disc herniation)
✕. Lack of capacity (e.g. significant cognitive impairment

What they're measuring

Change from baseline on the Numerical Rating Scale (NRS) for pain intensity

Timeframe: Baseline and at 4, 6, 8, 10, 52, 104 weeks post-surgery

Trial details

NCT IDNCT06390150

SponsorNova Scotia Health Authority

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-06

Contact for this trial

Lutz Weise, MD, PhD

902-472-6850 ally.klassen@nshealth.ca

View on ClinicalTrials.gov More Pain, Postoperative trials