Reconstruction of Deficient Interdental Papilla Using Stem Cells vs Physiological Saline

Inclusion Criteria: * Adults aged 20 - 40 years * Non-smoker * Able to understand English * Subjects who are able to attend follow up during the clinical trial * Subjects who are able to maintain oral hygiene (\< 10% FMPS) with BPE score 0, 1, or 2 at the upper anterior or lower anterior sextant * Subjects having at least one deficient interdental papilla in the upper or lower arch or both in the anterior region (from canine to contralateral canine) with papillary deficiency type I or II, according to Nordland and Tarnow classification * No history of regular medication intake (nifedipine, calcium channel blockers, cyclosporine, phenytoin, etc) * Teeth free from caries, proximal restorations, fixed prosthesis or orthodontic fixed appliances (except for fixed retainer that does not encroach on black triangle) * No open contacts between affected teeth * No history of periodontal surgical or non-surgical treatment (Root surface debridement) over the last six months at the area of interest * Probing pocket depth ≤ 4mm without bleeding on probing at the area of interest Exclusion Criteria: * Passive smoker/ former smoker/ electronic smoker * Alcoholic * Pregnant or breastfeeding females * Subjects with current or previous drug intake that may predispose to gingival enlargement (nifedipine, calcium channel blockers, cyclosporin, phenytoin, etc) * Subjects with medical conditions that may affect periodontal healing/ Reconstruction (diabetes, cardiovascular disease, stroke, asthma…