WithdrawnNot Applicable

High Flow Nasal Cannula Rates in Pediatric Asthma

Stopped: No longer performing study due to lack of funding and protected research time by PI

United States0Started 2025-01-15

Plain-language summary

This is a randomized, open-label, 3-armed feasibility trial will examine conventional oxygen therapy (COT) vs high flow nasal cannula at 4L/min flow vs HFNC at 2L/kg/min flow (max 60L/min) in moderate to severe pediatric asthma exacerbations.

Who can participate

Age range2 Years – 17 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 2-17 years old with prior clinical diagnosis of asthma * Admitted to PICU on standard asthma therapy defined as continuous albuterol and systemic corticosteroids * Admitted to PICU on either COT or HFNC * Admitted to PICU from either Golisano Children's Hospital ED or as a transport from an outside hospital ED within 6 hours of initial presentation * PRAM score greater than or equal to 4 after completion of initial ED therapy Exclusion Criteria: * Admitted to the PICU on NIV or invasive mechanical ventilation * Admitted to the PICU from general floors or \> 6 hours from initial presentation * Presence of a tracheostomy or baseline NIV requirement * Pregnancy * Immunocompromised State

What they're measuring

Percent of participants enrolled

Timeframe: 12 months

Trial details

NCT IDNCT06379607

SponsorUniversity of Rochester

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-15

View on ClinicalTrials.gov More Pediatric Asthma trials