Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchy… (NCT06376396) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis
300 participantsStarted 2024-06
Plain-language summary
The goal of this clinical trial is to compare the combination albendazole and praziquantel versus albendazole alone in patients affected by neurocysticercosis.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Living in the study area for a continuous period of 3 years
* Adult aged 18 years and above
* Are willing and able to consent to this study
* Meet the definitions of active symptomatic NCC
* Have late onset of epilepsy or history of seizures, epileptic seizures
* Subjects willing to undergo diagnostic procedures
* Subjects medically stable enough for trial medication to be initiated
* Subjects willing to be hospitalized for 11-20 days to receive treatment for NCC
* Subjects willing to be followed up for one year following receipt of study medication
Exclusion Criteria:
* Women pregnant or breastfeeding
* Symptomatic NCC with cysts in extra-parenchymal location (sub-arachnoid and/or ventricles)
* Have uncontrolled hypertension and/or diabetes
* Have chronic consuming illness such as cancer or mental handicap to not allow them to follow the study instructions
* Have severe immunodeficiency eg. HIV/AIDS or Autoimmune diseases
* Already known allergies to albendazole or praziquantel
* Subject taking part in another clinical/pharmacological study in the 30 days preceding enrollment