The present study aims to assess, through a randomized controlled trial (RCT), the efficacy of transcranial alternating current stimulation (tACS) in enhancing the functional changes due to an intensive motor training in children and adolescents with Cerebral Palsy (CP). Particularly, in two different groups active or sham tACS will be paired with the Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) and we will assess the effects on the upper limbs motor ability and daily functioning in 6 to 17 years old patients with CP having mild-to moderate upper limb deficits. The investigators hypothesized that, thanks to the intensive bimanual training, both the active and the sham group will improve in motor functioning. However, in light of findings showing that tACS effectively improves motor learning, the investigators hypothesized that active tACS might improve in a greater and more lasting extent than sham tACS the motor functioning. Moreover, as suggested by previous studies investigating the effect of non-invasive brain stimulation (NIBS) in pediatric population, the investigators expected that the treatment will be safe and well tolerated. Such a result would encourage the use of NIBS to boost the rehabilitative training of motor abilities in children and adolescents with CP.
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Assisting Hand Assessment (AHA)
Timeframe: 1-2 days before the start of training (t0), 1-2 days after the end of the training (t1), three months after the end of the training (t2)
Box and Block Test (BBT)
Timeframe: 1-2 days before the start of training (t0), 1-2 days after the end of the training (t1), three months after the end of the training (t2)
Visuomotor task
Timeframe: 1-2 days before the start of training (t0), 1-2 days after the end of the training (t1), three months after the end of the training (t2)