Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine (NCT06365047) | Clinical Trial Compass
Active — Not RecruitingPhase 3
Dry Mouth Toothpaste Study - Comparing Two Toothpastes With Arginine
United States70 participantsStarted 2024-08-31
Plain-language summary
This is a clinical investigation to measure the changes in the oral environment resulting from a 3 month exposure to an arginine containing toothpaste. This study is a double blind, randomized controlled, parallel design. Seventy (70) male and female subjects who meet the inclusion/exclusion criteria will be enrolled in the study. Following oral health evaluations, subjects will be assigned to the treatment schedule and receive their assigned study product.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. Male or female volunteers 18- 80 years of age and in general good health.
✓. Willing and able to understand and sign the informed consent form.
✓. Subjects currently taking at least two medications known to cause xerostomia (dry mouth) as a side effect for the last three months.
✓. Be willing to conform to the study protocol and procedures.
✓. Polypharmacy subjects must score 4 or more on the VAS scale of 0-10 ("How severe is your dryness right now?").
✓. Flow of 5 minutes unstimulated saliva should be below 0.16 ml/min.
✓. No known history of allergy to personal care/consumer products or their ingredients, relevant to any ingredients in the test products as determined by the study examiner.
✓. Minimum of 10 teeth
Exclusion criteria
✕. Subjects unable to understand or unwilling to sign the informed consent form.
✕. Medical condition which requires premedication prior to dental visits/procedure.
✕. Active disease of the hard or soft oral tissues.
✕. History of salivary gland disease such as Sjogren's syndrome, Sarcoidosis, or Head and Neck Radiation Therapy.