Oral Curcumin for the Treatment of Pain of Thumb Base Joint (CMC) Arthritis (NCT06359665) | Clinical Trial Compass
By InvitationPhase 1
Oral Curcumin for the Treatment of Pain of Thumb Base Joint (CMC) Arthritis
United States100 participantsStarted 2025-02-01
Plain-language summary
The goal of this clinical trial is to learn about the use of turmeric (Curcumin) as a treatment for pain of thumb-joint arthritis. Turmeric is commonly being used as an over-the-counter treatment for musculoskeletal pain. Clinical trials have demonstrated a pain-relief benefit for knee osteoarthritis, however no clinical trial has been performed to establish efficacy of curcumin in humans for thumb-joint arthritis. The main question\[s\] it aims to answer are:
* Is Turmeric more effective than placebo at relieving pain for thumb-joint arthritis? A placebo is a look-alike substance that contains no active drug.
* Is Turmeric more effective than placebo at improving patient-reported outcomes for CMC arthritis?
* Is Turmeric safe for participants with thumb-joint arthritis?
Participants will:
* take 4 weeks of daily Turmeric capsules,
* take 4 weeks of daily placebo capsules
* answer daily surveys about how they are feeling and functioning.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Provision of signed and dated informed consent form.
✓. Stated willingness to comply with all study procedures and availability for the duration of the study.
✓. Male or female, aged 18 years or older.
✓. For females, must be willing to use an approved form of birth control during this study. Acceptable forms of birth control:
✓. For males, must be willing to not father a baby for the duration of the study and for 90 days after the last dose of study drug, or donate to a sperm back during this time. Must be willing to use an approved form of birth control during this time. Acceptable forms of birth control:
✓. Daily visual analog pain greater than 5 and ≤ 9 out of 10.
✓. Duration of pain for greater than 30 days.
✓. Presence of radiographically confirmed diagnosis of thumb basal joint arthritis
Exclusion criteria
✕. Participant does not speak English.
What they're measuring
1
Change from Baseline in Pain on the Visual Analog Pain (VAS) Score
Timeframe: Baseline and Week 4, Week 6
2
Change from Baseline in Pain on the Visual Analog Pain (VAS) Score - crossover condition