Neostigmine and Glycopyrrolate by Iontophoresis

Inclusion Criteria: * Male or female; * Age 18 to 89; * Chronic SCI (\>1 year post injury); * You have documented constipation/difficulty with bowel evacuation and/or experience pain, straining, or fecal incontinence. Exclusion Criteria: * Previous adverse reaction or hypersensitivity to electrical stimulation; * Known sensitivity (prior reaction or allergy) to neostigmine or glycopyrrolate * History of mechanical obstruction (physical blockage) of the GI or urinary tract (e.g., due to scar tissues forming after surgery, gallstones); * Myocardial infarction (heart attack) within 6 months of trial; * Malignant and/or uncontrollable hypertension (high blood pressure), defined as a blood pressure reading of 160/100 mmHg or higher with or without taking 3 or more different classes of anti-hypertensive medications (drugs used to treat high blood pressure); * Organ damage (heart \& kidney) and/or transient ischemic attack/cerebrovascular accident (TIA-CVA, or stroke) as a result of hypertension; * Known past history of coronary artery disease or bradyarrhythmia (slow heart rate); * Symptomatic orthostatic hypotension (low blood pressure with possible dizziness/fainting); * Deep brain stimulation; * Pregnancy (women who are sexually active and of childbearing potential must utilize a method of contraception and agree to maintain a contraceptive method until completion of the study); * Lactating, nursing females; * Inability to provide informed consent determined by Montreal Cogni…